The Crime Data Base is the computer database network that the Saturdays use to learn about the criminals they might come across, it is unlocked by an eye scan. Drew use it so to search for Doyle's profile to figure if Doyle is her brother. Zak mentions Interpol when accessing it in Guess Who's Going To Be Dinner indicating its their criminal data base.
TriviaIn the episode "Van Rook's Apprentice," when Drew Saturday is scanning the Crime Data Base, Hex, Enoch, and Dr. Animo from the original Ben 10 series are seen displayed. Its unknown if this is merely a homage by the producers or if the two series exist in the same canon, although not likely as Ben would have probably tried to help in bigger situations, then again it could be before Ben 10: Alien Force and Ben Doesnt have the omnitrix. They could also be look alikes.
UPDATE: It was shown that the two shows are indeed in the same continuity in the Ben 10 Omniverse episode "T.G.I.S.". Secret Saturdays takes place during the time Ben is without the Omnitrix.